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KMID : 0383819610080020116
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Tuberculosis and Respiratory Diseases
1961 Volume.8 No. 2 p.116 ~ p.117
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Part 2. Effect of Pyrazinamide on the Plasma Urate Level of the Rabbit, the Chicken and the Dog.
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장병하(張炳夏)/Ha Byung Jang
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Abstract
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In view of known species differences in renal handling of urate, the effect of PZA
was investigated in various animals to see if this drug also modifies the plasma level of
urate in rabbits, chickens or in dogs. In all species studied, PZA failed to alter the
plasma urate level, suggesting that this drug is not able to interfere with the urate
transport system in the kidney of these animals. Histological studies of various organs
in the rabbit showed that no pathological findings could be detected after the PZA
administration for 6 weeks, although the kidney showed a slight degree of degenerative
changes in the tubule. However, the observed changes in the kidney is not so marked
as to reach at any conclusion.
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KEYWORD
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